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Solid Line from GEA GroupComplete Solid Line from NRI
 Solid Dosage Form
    [Solid Line from GEA]
 
High End Complete Solid Line from Niro Pharma Systems, GEA Group:

Niro Pharma Systems is world leader in providing advanced processing solutions for solid dosage forms to the pharmaceutical industry. Niro Pharma Systems offers a wide range of solutions, from individual pieces of equipment to complete integrated plants.
 
Mixing / Blending:
Mixing and blending is an important unit operation of pharmaceutical production. To fulfill these requirements Niro Pharma Systems offers a wide range of requirement for blending and mixing.

High shear mixing Machine : The bottom driven PHARMA MATRIXTM from Aeromatic – Fielder and the top drieven ULTMA GRALTM from Collette are stand alone blender mimixers. Capacity: from 1 kg to several hundred kg/batch.

   
Drying:

Fluid bed Dryer: For optimum compatibility with existing plant control strartegies, fluid bed systems are available with a choice of manual or FDA cpmpliant automated controls. Progammable logic controller (PLC)  and PC-based options offer a wide range of recipe handling, data acquisition and network communication functions.

   

Tabletting:
Niro Pharma Systems offers a range of extremely reliable and flexible tablet presses.

  • Rotary tablet presses: MODULTM – a new philosophy in tablet production (Precise, rapid pressing of tablets). Capacity: from 10,000 to 1,000,000 tablets per hour.

  • Courtoy Bi-layer tablet presses: Automatic double – sided rotary tablet press for single and double layer tablets. 

   
Coating:
Treating the surface by means of a coating operation can change material characteristics. The PRECISION COATERTM
defines the state of the art for pharmaceutical coating technology. Capacity: 50g to several 100 kg/ batch

Top SPRAY COATERTM is a cost effective pellet coating machine (Top-spray fluid bed coating). Capacity: 50g to some tons per batch. 
   

Materials Handling: 
Materials handling has become increasingly important in modern productions of solid dosage forms. Niro Pharma Systems offers customized dispensing systems to automize one of the most vital operations in the production of solid dosage forms.

  • Dispensing Booth

  • Discharge Station (for dust free product transfer from container to downstream equipment).

  • High containment (HC) split disc valve.

  • Total containment (TC) split disc valve.

  • Bridge free discharging system.

  • Intermediate bulk containers (IBC, Containers for powders, liquids and tablets).

  • Pharma – charge drums ( for material handling of small quantities).

  • IBC wash stations.

   
One-Pot microwave / vacuum drying (Gentle drying of powders):
The bottom driven GP GENERAL PROCESSOR from Aeromatic – Fielder and the top driven ULTIMA PROTM from Collette incorporates high – shear granulation with vacuum and microwave drying option in a single one-pot processor for high containment.

Vacuum drying can be gas assisted to improve heat and mass transfer. Microwave drying is used to achieve times equal to conventional drying process and precise scale up of drying time periods. The swinging bowl of the ULTIMA PROTM offers very gentle mixing during drying which is specially of interest for mechanically sensitive materials or formuli.
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